Development and Exploration of Biomaterials in Shenzhen
The rapid development of biomaterials and biotechnology has provided important means for revealing life phenomena and life processes, which is the basis for tissue and organ regeneration and reconstruction, and so is the catalyst for a second life. This special issue “Development and Exploration of Biomaterials in Shenzhen” has published wonderful reports and extended content of the 2021 Shenzhen Biomedical Materials Annual Conference, so that the readers who were unable to attend due to the COVID-19 epidemic could also take a glimpse of this annual conference via the special issue.
Guest Editor
Haobo Pan, Professor
Director, Human Tissue and Organ Degeneration Research Center;
Director, Guangdong Marine Biomaterials Engineering and Technology Center;
Director, Shenzhen Key Laboratory of Marine Biomedical Materials;
Deputy Director of Institute of Biomedicine and Technology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Prof. Pan’s research focuses on regenerative biomaterials.
With the development of science and technology, orthopedic biomaterials have evolved from traditional inert materials into targeted functional regulating materials. During their degradation, the materials can also regulate the local bone metabolism and promote bone regeneration and functional reconstruction. Therefore, the development of intelligent materials will be the hot spot and the new direction of orthopedic biomaterials research in the next decade, while multidisciplinary integration is an inevitable trend for the orthopedic clinics.
China is in the leading position of the world in research of antibacterial medical metals, and their applications are expected to effectively reduce the incidences of bacterial infections related to medical devices or implants, which has great clinical values. This article briefly introduces the innovative researches and preliminary applications of Cu-bearing antibacterial medical metals in China, and analyzes the opportunities and challenges in the future.
Precision medicine is an important development direction of modern biomedicine, and the emergence of micro/nanorobots has promoted the development of precision medicine. These miniaturized robots are manufactured through self-assembly, electron beam deposition, and 3D printing, and they can initiate chemical reactions or move under the action of external fields such as ultrasound, light, magnetic and microorganisms (cells). They are widely used in biomedicine, they can load drug particles, biological reagents and living cells to achieve precise cargo delivery; perform operation and treat diseases as a small sized surgical tool; detect metal ions and other substances in organisms for early diagnosis of diseases; conduct medical imaging through different methods such as photoacoustic, magnetic resonance. In the past ten years, the research of micro/nano robots has made some progress in these areas, vigorously promoting the development of modern medicine.
3D printed bone tissue model is important to the pre-operation planning, precision intraoperative location and post-surgery assessment. However, to print the same scale bone tissue model of patients depends on a series of processing from the CT image scanning, 3D reconstruction, 3D printing to post processes of the printed model. In the process, the quality of CT images and 3D reconstruction directly affects the precision and quality of the 3D printed model, especially the selection of which CT image series is a key problem that needs to be answered. Through the comparison of 3D reconstruction results between the bone series and stand series of CT images shown that the standard series produce better quality than the bone series. The conclusion is that the standard series may produce reconstructed 3D model of bone tissue in a better way than the bone series. And the conclusion provides a scientific proof for the selection of CT image series during the 3D reconstruction.
