The ability to mimic the microenvironment of the human body through fabrication of scaffolds itself a great achievement in the biomedical field. However, the search for the ideal scaffold is still in its infant stage and there are significant challenges to overcome. In the modern era, scientific communities are more attracted to natural substances due to their excess biological ability, low cost, biodegradability, and lesser toxic than synthetic lab made products. Chitosan is a well-known polysaccharide that has recently grabbed high amount of attention for its biological activities, especially in 3D bone tissue engineering (BTE). Chitosan greatly matches with the native tissues and thus stands out as a popular candidate for bioprinting. This review focuses on the potential of chitosan based scaffolds advancement and the drawbacks in bone treatment. Chitosan-based nanocomposites have exhibited strong mechanical strength, water-trapping ability, cellular interaction, and biodegradability characteristics. Chitosan derivatives have also encouraged and provided different routes of treatment and enhanced biological activities. 3D tailored bioprinting have opened new doors to design and manufacture scaffolds of biological, mechanical, and topographical properties.