Cardiovascular disease is one of leading threats to human life and health. Tissue-engineered vascular scaffolds that can assist the regeneration/repair of disordered vessels have provided promising alternatives for cardiovascular disease treatment. However, existing tissue-engineered vascular scaffolds still confront grand challenges in interfacial adaptations, resulting in high risks of complications upon implantation and unsatisfactory translational application. Recently, tissue-engineered vascular scaffolds capable of programmed deformation have been emerging. Such scaffolds can not only dynamically adapt to three-dimensional vascular shapes with varying diameters but also orderly regulate behaviors and functions of vascular cells, offering new opportunities for addressing the grand challenges of interfacial adaptations. An overview of most-updated advances and perspectives of programmed deformed scaffolds for vascular tissue engineering will provide valuable inspirations to the development and translational applications of new generation of tissue-engineered vascular scaffolds.