Objective: to observe the effects of low-frequency electrical stimulation (LES) on healthy adult with somatosensory evoked potential (SEP) and motor evoked potential (MEP). Method: 25 healthy adults (thirteen males and twelve females, with a mean age of 42.9 and a standard deviation of 5.7) participated in the study. SEP and MEP were measured before and after the LES stimulation. Results: After LES, the latency of SEP and MEP for the stimulated side became shorter and the amplitude became greater. These changes in latency and amplitude were statistically significant (P<0.05). For the unstimulated side, the changes of SEP and MEP did not show statistically significant difference. Conclusion: The SEP and MEP parameters, especially the amplitude, can be used to evaluate the effect of LES on central nervous system (CNS).