首页 > 按期查看>2021年第4期 >93-101. DOI:10.12146/j.issn.2095-3135.20210427004
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利用细菌治疗肿瘤的研究进展
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基金项目:

深圳市科技创新委员会项目(KQTD2015033117210153)



Research Progress in Bacterial Tumor Therapy
Author:
  • HUANG Jiandong

    HUANG Jiandong

    School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong 999077, China; Guangdong Provincial Key Laboratory of Synthetic Genomics, CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China
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  • WEI Mengxi

    WEI Mengxi

    Guangdong Provincial Key Laboratory of Synthetic Genomics, CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China
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  • ZHOU Nan2

    ZHOU Nan2

    Guangdong Provincial Key Laboratory of Synthetic Genomics, CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China
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Funding:

Shenzhen Science Technology and Innovation Commission (KQTD2015033117210153)

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    摘要:

    目前用于治疗癌症的方法大多副作用大，且药物不能有效到达癌组织内部，治疗效果相当有限。细菌虽种类繁多，可利用性强，但其由于自身的生物性能不可控以及安全性等问题，在肿瘤治 疗方面受限。随着合成生物学的发展，可通过合成生物学的方法对细菌进行工程性改造，使之毒性减弱，靶向定位肿瘤，特异性感知病灶，精准定位于病灶。利用工程菌作为载体搭载药物，或者对细菌进行基因修饰来表达目的药物分子，释放治疗药物，将大大提高细菌治疗肿瘤的可利用性，并提升治疗效果。该文主要总结了近年来利用工程细菌治疗肿瘤的研究进展。

    Abstract:

    The efficacy of current anti-tumor therapies has suffered from possible side effects and the poor accessibility of drugs to the tumor core. Although a variety of bacteria in nature have the potential to be used as anti-tumor drugs, lacking controllability and potential safety issues have limited their usage in tumor treatment. With the development of synthetic biology, bacteria are extensively programmed under engineering disciplines to possess less toxicity and enhanced ability to target tumors, sense the lesions and locate the lesions accurately. Applying engineered bacteria as vectors to directly carry drugs or express and release molecular therapeutics has greatly improved the efficacy of the tumor treatment. This article will summarize the recent progress in engineering bacteria for the treatment of tumors.

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引文格式
黄建东,韦孟溪,周 楠.利用细菌治疗肿瘤的研究进展 [J].集成技术,2021,10(4):93-101

Citing format
HUANG Jiandong, WEI Mengxi, ZHOU Nan. Research Progress in Bacterial Tumor Therapy[J]. Journal of Integration Technology,2021,10(4):93-101

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  • 在线发布日期: 2021-07-26

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