An oil-soluble polyether ester was synthesized according to the actual working conditions of the refrigerator, and the basic physical and chemical properties of synthetic esters were detected by national standards. To obtain the viscosity of pentaerythritol esters and polyether esters under various pressure of propane (R290), a laboratory-made lubricants-refrigerant online viscosity measurement system has been employed to measure the viscosity of the liquid fraction. Stability under practical conditions was tested by a sealed tube. It shows that the overall performance of polyether ester is better than the reference oil. Properties of the tribology have been tested by the four-ball wear tester. The results show that the wear amount of the polyether ester is less than the mineral oil and polyol esters, and polyether esters have better viscosity characteristics. The cooling efficiency is increased by 1.7% compared to mineral oil in the propane refrigeration system.